The genus Trillium was traditionally in the family Liliaceae, but at that time the Lily Family was a catch-all for lots of different kinds of monocots. Today it is either considered to be in its own family, Trilliaceae, or in the family Melanthiaceae. In either case, Trillium are closely related to the newer, more specific Lily Family.
The closely related genus Paris occurs in eastern Asia. The genus Trillium today has species in Japan and in western North America, but its main concentration seems to be southeastern North America.
Distribution of haplotypes of Trillium grandiflorum